Cisplatin renal clearance
WebApr 12, 2024 · OCT2 exerts its action through cisplatin transport into renal tubular epithelial cells . Consequently, OCT2 is responsible for the cellular uptake of cisplatin and, thus, for its intracellular accumulation. ... Indeed, from 5% to 15% of the patients with both estimated creatinine clearance (eCrCl), expressed in milliliters/minute, ... WebJan 7, 2024 · Most patients had oropharyngeal cancer, 35 patients in the mannitol group and 26 patients in the non-mannitol group. All patients were Caucasian. After the third series of cisplatin, the mean value of 51 Cr-EDTA clearance had declined to 92.3 mL/min (23.1) in the non-mannitol group and to 96.4 mL/min (20.8) in the mannitol group. The ...
Cisplatin renal clearance
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WebRenal clearance is most commonly a feature of polar, low LogD 7.4 (<~1) ... Renal clearance accounts for more than 90% of the clearance of platinum agents.[47] … WebSep 15, 2024 · Cisplatin is a prescription medicine used to treat the symptoms of cancer in the testicles (Metastatic Testicular Tumors), bladder (Advanced Bladder Cancer) and ovaries (Metastatic Ovarian Carcinoma). Cisplatin may be …
WebThe parent compound, cisplatin, is excreted in the urine and accounts for 13% to 17% of the dose excreted within one hour after administration of 50 mg/m 2 The mean renal clearance of... WebThe clearance (or total clearance) of a drug is the sum of the clearances of the eliminating organs, mainly the kidneys and the liver: CL = CL renal+CL hepatic. The hepatic clearance tends to be lower in elderly than in younger patients but that is …
WebThe renal clearance of free (ultrafilterable) platinum also exceeds the glomerular filtration rate indicating that cisplatin or other platinum-containing molecules are … WebIn the kidney, cisplatin is absorbed by renal cells via passive diffusion. During excretion, cisplatin and its metabolites are secreted and reabsorbed in the renal tubules during …
WebSep 21, 2016 · Purpose Efficacy of formulas calculating creatinine clearance (CrCl) to determine renal function eligibility (CrCl > 60 mL/min) for cisplatin-based chemotherapy has not been examined adequately in the bladder cancer population. We hypothesize these formulas may underestimate measured CrCl, and therefore the eligibility for cisplatin …
WebMay 8, 2024 · Deliver hydration to patients receiving cisplatin therapy to maintain renal function. Include magnesium supplementation, which has nephroprotective effects in adults, in hydration regimens before, during, and after cisplatin. Add mannitol to hydration to prevent nephrotoxicity in adults. Evidence for Interventions to Prevent Nephrotoxicity how is acute kidney injury diagnosedWebPhase Ib/II Study of Neoadjuvant Pembrolizumab With Gemcitabine-Cisplatin (Cisplatin-Eligible) or Gemcitabine (Cisplatin-Ineligible) in Subjects With T2-4aN0M0 Urothelial Cancer: HCRN GU14-188 ... Renal: Measured or calculated creatinine clearance ≥30 mL/min; ... Glomerular filtration rate (GFR) or creatinine clearance (Ccr) ≥ 50 mL/min ... how is a curve calculatedhigh how are you in russianWebThe mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and 50 mL/min/m 2 following administration of 100 mg/m 2 as 2 hour or 6 hour to 7 hour infusions, respectively. The renal clearance of free … how is acute compartment syndrome diagnosedWebFeb 16, 2024 · This drug can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate hydration and … how is a custodial account taxedWebMay 18, 2024 · When the initial dosage of cisplatin is more than 50 mg/m 2, the decrease of a cisplatin clearance rate, the increase of the cisplatin maximum plasma concentration, 83 the increase of the ultrafilterable cisplatin concentration caused by anemia, and the decrease of plasma albumin, 82 may be all pharmacokinetic bases for the increase of … highhow cafeWebJan 11, 2024 · According to current clinical trial eligibility criteria, patients with muscle-invasive bladder cancer (MIBC) and baseline renal clearance of 40–60 ml/min can … how is a cystogram performed