WebDec 17, 2024 · Furthermore, no matter LY294002, an inhibitor of the PI3K/AKT signaling pathway, or Venetoclax, a selective Bcl-2 inhibitor, protected against cardiac hypertrophy. In conclusion, these data indicate that Bcl-2 is involved in cardiac hypertrophy as a key downstream effector of PI3K-Akt signaling pathway, suggesting a potential therapeutic … WebApr 20, 2016 · In addition, tumour suppressor PDCD4 modulates miR-184-mediated direct suppression of c-MYC and BCL2-blocking cell growth and survival 11. ... CST) in PBS for 2 hrs at RT. After three washes in PBS, the coverslips were incubated for 1 h in the dark room with Alexa Fluor 488 goat anti-rabbit IgG (1:500, Bioworld Technology, Inc.). Further, the ...
Bcl-2 Antibody Cell Signaling Technology 2876S product …
WebDec 27, 2024 · A Western blot analysis for Bcl2, Bax, and cleaved caspase-3 (CC3). B Quantification of Bcl2, Bax, and CC3. C Representative photomicrographs of immunofluorescence staining for CC3 and E TUNEL staining in different groups. D, F Semi-quantitative analysis of CC3 immunofluorescence staining and TUNEL staining. n = 6 for … WebMar 1, 2024 · The antiapoptotic members of the BCL-2 family, including BCL-2 and BCL-X L, exert their survival functions by binding and neutralizing the apoptotic effectors BAX and BAK. We have previously demonstrated that the 14 PDX models express different levels of the BCL-2 family proteins and show a wide range of sensitivity to the dual BCL-2/X L ... florida lotto winners names
Bcl-2 Antibody Cell Signaling Technology
WebDespite comprehensive genomic analyses, no targeted therapies are approved for bladder cancer. Here, we investigate whether a single and combination therapy with targeted agents exert antitumor effects on bladder cancer cells through genomic alterations using a three-dimensional (3D) high-throughput screening (HTS) platform. Seven human bladder … WebMay 20, 2024 · TP-53 controls apoptosis upstream of where BCL-2 and its prosurvival relatives, such as MCL-1, act. Therefore, targeting these prosurvival proteins could trigger apoptosis across diverse blood cancers, irrespective of TP53 mutation status. Indeed, targeting BCL-2 has produced clinically relevant responses in blood cancers with … WebAug 5, 2024 · The antibody dilution ratio was as follows: eIF3c (1:500, Cell Signaling Technology, CST), Bax (1:1000, CST), Bcl2 (1:1500, Abcam), cleaved caspase 3 (1:1000, Cell Signaling Technology, CST) and β-actin (1:5000, CST). Statistical analysis. Data are presented as the mean ± SEM from at least three independent experiments. greatway advisor webmail